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Levetiracetam inhibits interleukin-1beta inflammatory responses in the hippocampus and piriform cortex

by Romeo Mariano, MD (January 20, 2010)

Levetiracetam inhibits interleukin-1beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. Neurosci Lett. 2010 Jan 14; Authors: Kim JE, Choi HC, Song HK, Jo SM, Kim DS, Choi SY, Kim YI, Kang TC Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra(R), UCB Pharma) is a new antiepileptic drug used to treat certain types of seizures in [...]

BDNF variant from Val66Met polymorphism reduces HPA-axis reactivity to acute stress.

by Romeo Mariano, MD (January 19, 2010)

The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress. Psychoneuroendocrinology. 2010 Jan 13; Authors: Alexander N, Osinsky R, Schmitz A, Mueller E, Kuepper Y, Hennig J BACKGROUND: Growing evidence suggests that individual differences in HPA-axis reactivity to psychosocial stress are partly due to heritable influences. However, knowledge about the role of specific genetic variants [...]

The major mood disorders have significant genetic overlap

by Romeo Mariano, MD (January 19, 2010)

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1 Nature Genetics Published online: 17 January 2010 | doi:10.1038/ng.523 Francis J McMahon1, Nirmala Akula1, Thomas G Schulze1,2, Pierandrea Muglia3,4, Federica Tozzi3, Sevilla D Detera-Wadleigh1, C J M Steele1, René Breuer2, Jana Strohmaier2, Jens R Wendland1, Manuel Mattheisen5,6,7, Thomas W Mühleisen5,6, [...]

Methylprednisolone reduces nitric oxide formation in cytokine-stimulated oligodendroglial cells

by Romeo Mariano, MD (January 18, 2010)

Effects of methylprednisolone and glatiramer acetate on nitric oxide formation of cytokine-stimulated cells from the rat oligodendroglial cell line OLN-93. Neuroimmunomodulation. 2010;17(1):23-30 Authors: Holzknecht C, Röhl C OBJECTIVES: In multiple sclerosis, an autoimmune inflammatory disease, oligodendroglia are primarily affected and play an important role in the onset and process of the degeneration of neuronal axons. [...]

Activated microglia increase excitability of rat hippocampal neurons by producing interleukin-1beta.

by Romeo Mariano, MD (January 18, 2010)

Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. Neuroimmunomodulation. 2010;17(1):31-8 Authors: Zheng H, Zhu W, Zhao H, Wang X, Wang W, Li Z OBJECTIVE: It is known that highly activated microglia and the consequent production of inflammatory cytokines were associated with neuroexcitotoxic injuries. The [...]

Inflammatory biomarkers in patients with posttraumatic stress disorder

by Romeo Mariano, MD (January 18, 2010)

Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms.: “ Neuroimmunomodulation. 2010;17(1):39-46 Authors: von Känel R, Begré S, Abbas CC, Saner H, Gander ML, Schmid JP OBJECTIVE: Inflammation might link posttraumatic stress disorder (PTSD) with an increased risk of cardiovascular events. We explored the association between [...]

Increased Pro-Inflammatory Activity underlying Posttraumatic Stress Disorder

by Romeo Mariano, MD (January 18, 2010)

Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res. 2007 Nov;41(9):744-52. Epub 2006 Aug 9. von Känel R, Hepp U, Kraemer B, Traber R, Keel M, Mica L, Schnyder U. Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital/INSELSPITAL, Freiburgstrasse 4, CH-3010 Berne, Switzerland. roland.vonkaenel@insel.ch Posttraumatic stress [...]

Pro-inflammatory cytokine activation of the hypothalamic-pituitary-adrenal axis via NF-kappaB and Nurr-1 expression

by Romeo Mariano, MD (January 18, 2010)

Involvement of Nuclear Factor-kappaB and Nurr-1 in Cytokine-Induced Transcription of Proopiomelanocortin Gene in AtT20 Corticotroph Cells. Neuroimmunomodulation. 2009 Nov 17;17(2):88-96 Authors: Takayasu S, Iwasaki Y, Nigawara T, Asai M, Yoshida M, Kageyama K, Suda T Objective: The precise mechanism whereby proinflammatory cytokines activate the hypothalamo-pituitary-adrenal axis is still unclear. We examined whether transcription factors nuclear [...]

Testosterone improves Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men

by Romeo Mariano, MD (January 18, 2010)

Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men: A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Srinivas-Shankar U, Roberts SA, Connolly MJ, O’ Connell MD, Adams JE, Oldham JA, Wu FC Context: Physical frailty is associated with reduced [...]

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Thiazolidinedione associated with increased Risk of Fractures in Patients with Type 2 Diabetes Mellitus.

by Romeo Mariano, MD (January 18, 2010)

Thiazolidinedione Use and the Longitudinal Risk of Fractures in Patients with Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Habib ZA, Havstad SL, Wells K, Divine G, Pladevall M, Williams LK Context: Thiazolidinedione (TZD) use has recently been associated with an increased risk of fractures. Objective: The aim of this study [...]

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