NEW ARTICLES
Insomnia exacerbates fatigue, depression, pain, and rheumatoid arthritis.
This study provides the first evidence of an exaggerated increase in symptoms of mood and pain in patients with rheumatoid arthritis after sleep loss, along with an activation of rheumatoid arthritis-related joint pain. Given the reciprocal relationship between sleep disturbances and pain, clinical management of pain in patients with rheumatoid arthritis should include an increased focus on the prevention and treatment of sleep disturbance in this clinical population.
Sulfasalazine Inhibits Activation of NF-κB in Basolateral Amygdala, Impairing Memory Persistance in Auditory Fear Conditioning
Activation of NF-κB in Basolateral Amygdala Is Required for Memory Reconsolidation in Auditory Fear ConditioningPLoS One. 2012;7(9):e43973. Epub 2012 Sep 5.Si J, Yang J, Xue L, Yang C, Luo Y, Shi H, Lu L.Source Abstract Posttraumatic stress disorder (PTSD) is characterized by acute and chronic changes in the stress response, manifested as conditioned fear memory. [...]
Rice Protein Reduces Oxidative Stress
Rice protein improves oxidative stress by regulating glutathione metabolism and attenuating oxidative damage to lipids and proteins in rats Life Sci. 2012 Aug 11; Yang L, Chen JH, Xu T, Zhou AS, Yang HK Abstract AIMS: To evaluate the effects of rice protein (RP) on glutathione metabolism and oxidative damage. MAIN METHODS: Seven-week-old male Wistar [...]
B Vitamins Can Reduce Pain
B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats Life Sci. 2012 Aug 24; Kopruszinski CM, Reis RC, Chichorro JG Abstract AIMS: There is mounting evidence that use of B vitamins can help control neuropathic pain. This study investigated if treatment with B1, B6 and B12 vitamins, alone or in combination [...]
Seroquel Reduces Autoimmune-Mediated Demyelination and IL-2
Quetiapine, an Atypical Antipsychotic, Is Protective against Autoimmune-Mediated Demyelination by Inhibiting Effector T Cell Proliferation Feng Mei, Sheng Guo, Yangtao He, Linyun Wang, Hongkai Wang, Jianqin Niu, Jiming Kong, Xinmin Li, Yuzhang Wu, Lan Xiao PLoS One. 2012;7(8):e42746. Epub 2012 Aug 13. Abstract Quetiapine (Que), a commonly used atypical antipsychotic drug (APD), can prevent myelin [...]
Testosterone is anti-inflammatory
The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8 Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. Abstract Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNF-alpha, [...]
Stress, food, and inflammation
Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge Psychosom Med. 2010 May;72(4):365-9 Kiecolt-Glaser JK Abstract Inflammation is the common link among the leading causes of death. Mechanistic studies have shown how various dietary components can modulate key pathways to inflammation, including sympathetic activity, oxidative stress, transcription factor nuclear factor-kappaB activation, and [...]
Schizophrenia and anti-inflammatory therapy
Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: all make sense now? J Psychopharmacol. 2011 Jun;25(6):713-4 Müller N, Dursun SM Abstract Genetics, epigenetics, infection as an environmental factor, functional findings for the immune system, and a therapeutic approach with anti-inflammatory therapy provide evidence for a pivotal role of the immune system in schizophrenia. This field, therefore, should [...]
Psychoneuroimmunologic Factors In Inflammatory Bowel Disease
Psychoneuroimmunologic factors in inflammatory bowel disease Inflamm Bowel Dis. 2011 Mar;17(3):849-57 Authors: Mackner LM, Clough-Paabo E, Pajer K, Lourie A, Crandall WV Abstract BACKGROUND: Bidirectional relationships between the immune system, nervous system, and psychological processes likely exist in inflammatory bowel disease (IBD) because stress can affect IBD, and IBD is associated with an increased risk [...]
Berries and flavonoids reduce cognitive decline.
Dietary intakes of berries and flavonoids in relation to cognitive decline Ann Neurol. 2012 Jul;72(1):135-43 Authors: Devore EE, Kang JH, Breteler MM, Grodstein F Abstract OBJECTIVE: Berries are high in flavonoids, especially anthocyanidins, and improve cognition in experimental studies. We prospectively evaluated whether greater long-term intakes of berries and flavonoids are associated with slower rates [...]
Older Men Who Use Computers Have Lower Risk of Dementia
Older men who use computers have lower risk of dementia. PLoS One. 2012;7(8):e44239. Epub 2012 Aug 28. Almeida OP, Yeap BB, Alfonso H, Hankey GJ, Flicker L, Norman PE. OBJECTIVE:To determine if older men who use computers have lower risk of developing dementia. METHODS:Cohort study of 5506 community-dwelling men aged 69 to 87 years followed [...]
A comparison of psychiatry and internal medicine
A comparison of psychiatry and internal medicine: a bibliometric study Acad Psychiatry. 2012 Mar 1;36(2):129-32 Stone K, Whitham EA, Ghaemi SN Abstract OBJECTIVE: Psychiatric education needs to expose students to a broad range of topics. One resource for psychiatric education, both during initial training and in later continuing medical education, is the scientific literature, as [...]
Reduced GABA Concentration in Attention-Deficit/Hyperactivity DisorderReduced GABA Concentration in ADHD.
Reduced GABA Concentration in Attention-Deficit/Hyperactivity DisorderReduced GABA Concentration in ADHD Arch Gen Psychiatry. 2012 Jul 1;69(7):750-3 Authors: Edden RA, Crocetti D, Zhu H, Gilbert DL, Mostofsky SH Abstract CONTEXT Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by a deficit in behavioral inhibition. Recent evidence also suggests a deficit in cortical inhibition via the GABA [...]
Losartan Reduces Fibrosis and Improves Muscle Strength in Muscular Dystrophy Model
Losartan, a therapeutic candidate in congenital muscular dystrophy: studies in the dy(2J) /dy(2J) mouse Ann Neurol. 2012 May;71(5):699-708 Elbaz M, Yanay N, Aga-Mizrachi S, Brunschwig Z, Kassis I, Ettinger K, Barak V, Nevo Y Abstract OBJECTIVE: Lamininα2-deficient congenital muscular dystrophy type 1A (MDC1A) is a cureless disease associated with severe disability and shortened lifespan. Previous [...]
Vitamin D Reduces Multiple Sclerosis Lesions
Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis Ann Neurol. 2012 Aug;72(2):234-40 Mowry EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR, Gourraud PA, Brenneman D, Owen MC, Qualley P, Bucci M, Hauser SL, Pelletier D Abstract OBJECTIVE: We sought to determine whether vitamin D status is associated [...]
Inflammatory Cytokine Cause Cognitive Impairment, Depression, And Sleep Disturbance And Other Non-Motor Symptoms Of Parkinsons Disease
The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson’s disease. Psychosomatics. 2010 Nov-Dec;51(6):474-9. Menza M, Dobkin RD, Marin H, Mark MH, Gara M, Bienfait K, Dicke A, Kusnekov A. Abstract BACKGROUND:Parkinson’s disease (PD) affects patients’ lives with more than just physical impairment. Many of the non-motor aspects of PD, such as [...]
Viagra Reduces Insulin Resistance in Endothelial Cells
Sildenafil reduces insulin-resistance in human endothelial cells PLoS One. 2011 Jan 28;6(1):e14542.Mammi C, Pastore D, Lombardo MF, Ferrelli F, Caprio M, Consoli C, Tesauro M, Gatta L, Fini M, Federici M, Sbraccia P, Donadel G, Bellia A, Rosano GM, Fabbri A, Lauro D. Abstract BACKGROUND:The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function [...]
