Originally Posted by hardasnails1973
When a women is experiencing excessive hair loss when iron is not helping could this be hormonally related as to thyroid and progesterone. In a women just how important is the proper progesterone and estrodial balance for proper thyroid functioning at the receptor. If the balance is very skewed to more estradial would this result in a hypo functioning thyroid at the tissue level even though all parameters of thyroid are in healthy levels? What are some of physiological and psychological effects have you notice clinicially in women that have estrodial tends to dominate progesterone despite normal thyroid function. I have read a lot of information on the internet, but I prefer to hear from a clinical stand point.
Nutrition is balanced
lack of exercise due to demanding work schedule
High stress demand (slighly elevated cortisol on saliva test)
Excessive hair loss in clumps, weight gain, emotional out burst during period, mental confusion, dry skin, forgetfulness, premature agiing, PMS symptoms that require percocet to counter act the pain, high anxiety.
Started on progesterone due to estradiol imbalance for 7 months, but could not continue therapy due to financial reasons. Since stopping the progesterone for 2 month all of the symptoms return worse then before. What kind of hormonal havoc could abruptly stopping the progesterone due to a female? Would this be similar to stopping testosterone cold turkey in a male?
I currently have only a short time to reply. The subject is deeper, of course.
Premenstrual dysphoric disorder occurs when there is dysfunction in three circuits: thyroid, nervous system, adrenals. The dysfunction is exacerbated by the higher levels of estradiol during the luteal phase of the menstrual period. Estrogen levels do not need to be excessively high for this to occur. But the loss of adrenal cortex produced progesterone allows estrogen to excessively thicken the endometrium, resulting in cramps and heavy flow, as well as contribute to mood destabilization.
Progesterone, in women, is a good option to cortisol, in supporting adrenal cortex function.
Emotional instability indicates excessive norepinephrine signaling/stress signaling with inadequate anti-stress response from the rest of the system (nervous system, endocrine system, immune system, etc.)
Progesterone increase estrogen receptors. The loss of progesterone causes a reduction in sensitivity to estrogen - a functional loss of estrogen signaling.
Excessive estrogen can destabilize mood, increasing stress - through direct effects on the nervous system, by affecting thyroid hormone signaling, by increasing immune system activation, etc.
Common causes of hair-loss in women include:
- loss of estrogen (estrogen prolongs the growth phase of hair)
- low thyroid (excessive thyroid can also cause hair loss).
- loss of zinc (from stress-induced insulin resstance, causing clumps of hair to be lost).
- suboptimal iron (e.g. iron deficiency)
- suboptimal Biotin
- suboptimal Linoleic acid (omega-6)
- suboptimal Lysine
Over-the-counter 2% Progesterone skin cream is an option for many women.
Romeo B. Mariano, MD, physician, psychiatrist
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