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Psychoimmunology

Activated microglia increase excitability of rat hippocampal neurons by producing interleukin-1beta.

by Romeo Mariano, MD (January 18, 2010)

Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. Neuroimmunomodulation. 2010;17(1):31-8 Authors: Zheng H, Zhu W, Zhao H, Wang X, Wang W, Li Z OBJECTIVE: It is known that highly activated microglia and the consequent production of inflammatory cytokines were associated with neuroexcitotoxic injuries. The [...]

Inflammatory biomarkers in patients with posttraumatic stress disorder

by Romeo Mariano, MD (January 18, 2010)

Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms.: “ Neuroimmunomodulation. 2010;17(1):39-46 Authors: von Känel R, Begré S, Abbas CC, Saner H, Gander ML, Schmid JP OBJECTIVE: Inflammation might link posttraumatic stress disorder (PTSD) with an increased risk of cardiovascular events. We explored the association between [...]

Increased Pro-Inflammatory Activity underlying Posttraumatic Stress Disorder

by Romeo Mariano, MD (January 18, 2010)

Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res. 2007 Nov;41(9):744-52. Epub 2006 Aug 9. von Känel R, Hepp U, Kraemer B, Traber R, Keel M, Mica L, Schnyder U. Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital/INSELSPITAL, Freiburgstrasse 4, CH-3010 Berne, Switzerland. roland.vonkaenel@insel.ch Posttraumatic stress [...]

Pro-inflammatory cytokine activation of the hypothalamic-pituitary-adrenal axis via NF-kappaB and Nurr-1 expression

by Romeo Mariano, MD (January 18, 2010)

Involvement of Nuclear Factor-kappaB and Nurr-1 in Cytokine-Induced Transcription of Proopiomelanocortin Gene in AtT20 Corticotroph Cells. Neuroimmunomodulation. 2009 Nov 17;17(2):88-96 Authors: Takayasu S, Iwasaki Y, Nigawara T, Asai M, Yoshida M, Kageyama K, Suda T Objective: The precise mechanism whereby proinflammatory cytokines activate the hypothalamo-pituitary-adrenal axis is still unclear. We examined whether transcription factors nuclear [...]

Obesity with Insulin Resistance Is Associated with a Proinflammatory and Prothrombotic State

by Romeo Mariano, MD (January 18, 2010)

Obesity without Established Comorbidities of the Metabolic Syndrome Is Associated with a Proinflammatory and Prothrombotic State, Even before the Onset of Puberty in Children. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Mauras N, Delgiorno C, Kollman C, Bird K, Morgan M, Sweeten S, Balagopal P, Damaso L Background: Metabolic syndrome (MS)-related comorbidities in obesity, [...]

Stress, Inflammation, and Yoga Practice.

by Romeo Mariano, MD (January 17, 2010)

Stress, Inflammation, and Yoga Practice.: “ Psychosom Med. 2010 Jan 11; Authors: Kiecolt-Glaser JK, Christian L, Preston H, Houts CR, Malarkey WB, Emery CF, Glaser R Objective: To address the mechanisms underlying hatha yoga’s potential stress-reduction benefits, we compared inflammatory and endocrine responses of novice and expert yoga practitioners before, during, and after a restorative [...]

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Pyrogenic cytokines did not mediate a stress interview-induced hyperthermic response in a patient with psychogenic fever: a case report.

by Romeo Mariano, MD (January 17, 2010)

Pyrogenic cytokines did not mediate a stress interview-induced hyperthermic response in a patient with psychogenic fever: a case report. Psychosom Med. 2009 Nov;71(9):932-6 Authors: Hiramoto T, Oka T, Yoshihara K, Kubo C OBJECTIVE: To investigate if pyrogenic cytokines mediated psychological stress-induced hyperthermic response in a patient with psychogenic fever. Despite many case reports on psychogenic [...]

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Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids

by Romeo Mariano, MD (January 17, 2010)

Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: insights from in vivo cell trafficking dynamics in rhesus macaques. Psychosom Med. 2009 Jul;71(6):591-7 Authors: Cole SW, Mendoza SP, Capitanio JP OBJECTIVE: To determine whether chronic social stress can desensitize leukocytes to normal physiologic regulation by endogenous glucocorticoids. METHODS: We analyzed the longitudinal relationship between plasma [...]

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Cytokine polymorphisms in the pathophysiology of mood disorders.

by Romeo Mariano, MD (January 17, 2010)

Cytokine polymorphisms in the pathophysiology of mood disorders. CNS Spectr. 2009 Aug;14(8):419-25 Authors: Clerici M, Arosio B, Mundo E, Cattaneo E, Pozzoli S, Dell’osso B, Vergani C, Trabattoni D, Altamura AC INTRODUCTION: An increasing amount of data suggests that dysregulation of the immune system, including the cytokine network, is associated with the etiology and pathophysiology [...]

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Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production.

by Romeo Mariano, MD (January 13, 2010)

Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production. Related Articles Biol Psychol. 2009 Sep;82(1):12-7 Authors: Prather AA, Marsland AL, Hall M, Neumann SA, Muldoon MF, Manuck SB Activation of innate inflammatory pathways, marked by increased production of pro-inflammatory cytokines, has been proposed as a potential mechanism linking [...]

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