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Psychiatry

Activated microglia increase excitability of rat hippocampal neurons by producing interleukin-1beta.

by Romeo Mariano, MD (January 18, 2010)

Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. Neuroimmunomodulation. 2010;17(1):31-8 Authors: Zheng H, Zhu W, Zhao H, Wang X, Wang W, Li Z OBJECTIVE: It is known that highly activated microglia and the consequent production of inflammatory cytokines were associated with neuroexcitotoxic injuries. The [...]

Inflammatory biomarkers in patients with posttraumatic stress disorder

by Romeo Mariano, MD (January 18, 2010)

Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms.: “ Neuroimmunomodulation. 2010;17(1):39-46 Authors: von Känel R, Begré S, Abbas CC, Saner H, Gander ML, Schmid JP OBJECTIVE: Inflammation might link posttraumatic stress disorder (PTSD) with an increased risk of cardiovascular events. We explored the association between [...]

Increased Pro-Inflammatory Activity underlying Posttraumatic Stress Disorder

by Romeo Mariano, MD (January 18, 2010)

Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res. 2007 Nov;41(9):744-52. Epub 2006 Aug 9. von Känel R, Hepp U, Kraemer B, Traber R, Keel M, Mica L, Schnyder U. Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital/INSELSPITAL, Freiburgstrasse 4, CH-3010 Berne, Switzerland. roland.vonkaenel@insel.ch Posttraumatic stress [...]

Pro-inflammatory cytokine activation of the hypothalamic-pituitary-adrenal axis via NF-kappaB and Nurr-1 expression

by Romeo Mariano, MD (January 18, 2010)

Involvement of Nuclear Factor-kappaB and Nurr-1 in Cytokine-Induced Transcription of Proopiomelanocortin Gene in AtT20 Corticotroph Cells. Neuroimmunomodulation. 2009 Nov 17;17(2):88-96 Authors: Takayasu S, Iwasaki Y, Nigawara T, Asai M, Yoshida M, Kageyama K, Suda T Objective: The precise mechanism whereby proinflammatory cytokines activate the hypothalamo-pituitary-adrenal axis is still unclear. We examined whether transcription factors nuclear [...]

Testosterone improves Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men

by Romeo Mariano, MD (January 18, 2010)

Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men: A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Srinivas-Shankar U, Roberts SA, Connolly MJ, O’ Connell MD, Adams JE, Oldham JA, Wu FC Context: Physical frailty is associated with reduced [...]

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Thiazolidinedione associated with increased Risk of Fractures in Patients with Type 2 Diabetes Mellitus.

by Romeo Mariano, MD (January 18, 2010)

Thiazolidinedione Use and the Longitudinal Risk of Fractures in Patients with Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Habib ZA, Havstad SL, Wells K, Divine G, Pladevall M, Williams LK Context: Thiazolidinedione (TZD) use has recently been associated with an increased risk of fractures. Objective: The aim of this study [...]

Long-Term Growth Hormone Therapy Improves Body Composition and Motor Function

by Romeo Mariano, MD (January 18, 2010)

Long-Term Growth Hormone Therapy Changes the Natural History of Body Composition and Motor Function in Children with Prader-Willi Syndrome. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Carrel AL, Myers SE, Whitman BY, Eickhoff J, Allen DB Background: Children with Prader-Willi syndrome (PWS) have decreased muscle mass, hypotonia, and impaired linear growth. Recombinant human GH [...]

Low Total Testosterone increases risk for Abdominal Aortic Aneurysm

by Romeo Mariano, MD (January 18, 2010)

Associations of Total Testosterone, Sex Hormone-Binding Globulin, Calculated Free Testosterone, and Luteinizing Hormone with Prevalence of Abdominal Aortic Aneurysm in Older Men. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Yeap BB, Hyde Z, Norman PE, Chubb SA, Golledge J Context: Abdominal aortic aneurysm (AAA) is associated with mortality in older adults, and increasing aortic [...]

Leptin Prevents Weight Loss-Induced Slowing of Metabolism

by Romeo Mariano, MD (January 18, 2010)

Leptin Replacement Prevents Weight Loss-Induced Metabolic Adaptation in Congenital Leptin-Deficient Patients. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Galgani JE, Greenway FL, Caglayan S, Wong ML, Licinio J, Ravussin E Context: Leptin regulates energy homeostasis by suppressing food intake; however, its role in energy expenditure and fat oxidation remains uncertain in humans. Objective: The [...]

Obesity with Insulin Resistance Is Associated with a Proinflammatory and Prothrombotic State

by Romeo Mariano, MD (January 18, 2010)

Obesity without Established Comorbidities of the Metabolic Syndrome Is Associated with a Proinflammatory and Prothrombotic State, Even before the Onset of Puberty in Children. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Mauras N, Delgiorno C, Kollman C, Bird K, Morgan M, Sweeten S, Balagopal P, Damaso L Background: Metabolic syndrome (MS)-related comorbidities in obesity, [...]

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