From the category archives:

Nutrition

Reducing dietary sodium: the case for caution.

by Romeo Mariano, MD (February 21, 2010)

Reducing dietary sodium: the case for caution.

JAMA. 2010 Feb 3;303(5):448-9
Authors: Alderman MH
QUOTE:
Multiple randomized clinical trials (RCTs) have established that reduction of sodium intake sufficient to lower blood pressure also increases sympathetic nerve activity, decreases insulin sensitivity, activates the renin angiotensin system, and stimulates aldosterone secretion.
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Low salt diets lead to:
Increased sympathetic nervous system activity - [...]

Low Serum Folate Levels as a Risk Factor for Depression

by Romeo Mariano, MD (February 21, 2010)

Low Serum Folate Levels as a Risk Factor for Depressive Mood in Patients With Chronic Epilepsy
J Neuropsychiatry Clin Neurosci 15:64-66, February 2003
Johannes Rösche, Dr.med., M.A., Carmen Uhlmann, Dr.hum.biol., Dipl.Psych. and Walter Fröscher, Prof.Dr.med.
This study takes into consideration whether low serum folate levels may contribute to depressive mood in patients with chronic epilepsy.
The serum folate [...]

Gut microbes enhance the immune system

by Romeo Mariano, MD (February 7, 2010)

Gut microbes extend reach to systemic innate immunity
Nature Medicine 16, 160 (2010).
Authors: Dana J Philpott & Stephen E Girardin
Microbes in the gut can influence distant events, affecting the function of neutrophils in the circulation of mice (pages 228-231). The findings should lead to new studies examining how intestinal microbes affect immunity.
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Recognition of peptidoglycan from the [...]

Selenium slows memory decline - Reducing acetylcholinesterase activity

by Romeo Mariano, MD (February 7, 2010)

Organoselenium improves memory decline in mice: Involvement of acetylcholinesterase activity.
Neurosci Lett. 2010 Jan 29;
Authors: Pinton S, Rocha JT, Zeni G, Nogueira CW
The present study was designed to investigate the possible neuroprotective effect of p,p’-methoxyl-diphenyl diselenide [(MeOPhSe)(2)] in a model of sporadic dementia of Alzheimer’s type (SDAT) induced by intracerebroventricular (i.c.v.) injection of streptozotocin (STZ) [...]

Selenium prevents cognitive decline and oxidative damage

by Romeo Mariano, MD (February 7, 2010)

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type.
Brain Res. 2009 Jul 24;1281:117-27. Epub 2009 Apr 15.
Ishrat T, Parveen K, Khan MM, Khuwaja G, Khan MB, Yousuf S, Ahmad A, Shrivastav P, Islam F.
Department of Medical Elementology and Toxicology, Neurotoxicology Laboratory, Jamia Hamdard (Hamdard University), New Delhi, [...]

Supressing HPA Axis Activity via Exogenous Cortisol Enhances Aggressive Behavior in Females, but not in Males.

by Romeo Mariano, MD (February 6, 2010)

Exogenous cortisol enhances aggressive behavior in females, but not in males.
Psychoneuroendocrinology. 2010 Feb 1;
Böhnke R, Bertsch K, Kruk MR, Richter S, Naumann E
The hypothalamic-pituitary-adrenal (HPA) axis plays a major role in the development, elicitation, and enhancement of aggressive behavior in animals.
Increasing evidence suggests that this is also true for humans.
Here, we report on [...]

Omega-3 Fatty Acids for Prevention of Psychotic Disorders

by Romeo Mariano, MD (February 6, 2010)

Long-Chain {omega}-3 Fatty Acids for Indicated Prevention of Psychotic Disorders: A Randomized, Placebo-Controlled Trial.
Arch Gen Psychiatry. 2010 Feb;67(2):146-54
Amminger GP, Schäfer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE
CONTEXT: The use of antipsychotic medication for the prevention of psychotic disorders is controversial.
Long-chain omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) [...]

Blueberry Juice May Boost Memory

by Romeo Mariano, MD (January 27, 2010)

Blueberry Juice May Boost Memory
(Via WebMD Health.)
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Blueberry Supplementation Improves Memory in Older Adults
J Agric Food Chem. 2010 Jan 4. [Epub ahead of print]
Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA.
The prevalence of dementia is increasing with expansion of the older adult population. In the absence of effective therapy, preventive [...]

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Omega-3 Fatty Acids improve macro- and microvascular function in subjects with type 2 diabetes mellitus.

by Romeo Mariano, MD (January 17, 2010)

Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus.

Am J Clin Nutr. 2010 Jan 13;
Authors: Stirban A, Nandrean S, Götting C, Tamler R, Pop A, Negrean M, Gawlowski T, Stratmann B, Tschoepe D
BACKGROUND: Recent evidence supports the protective effects of n-3 (omega-3) fatty acids (n-3 FAs), [...]

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Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations.

by Romeo Mariano, MD (January 13, 2010)

Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations.

Arch Neurol. 2010 Jan;67(1):126-30
Authors: Debs R, Depienne C, Rastetter A, Bellanger A, Degos B, Galanaud D, Keren B, Lyon-Caen O, Brice A, Sedel F
OBJECTIVE: To report the first 2 European cases of biotin-responsive basal ganglia disease and novel SLC19A3 mutations.
DESIGN: Case reports.
SETTING: [...]

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