Category: Neurology
Low-Dose Aripiprazole in the Treatment of SSRI-Induced Bruxism.
Bruxism is characterized by involuntary, repetitive movements of jaw-clenching and teeth-grinding. Several reports in the literature suggest that selective serotonin reuptake inhibitors (SSRIs) might induce bruxism. In that event, clinicians face difficult treatment decisions, especially in cases whereby SSRIs cannot be discontinued or decreased, as in obsessive-compulsive disorder (OCD). In the following, we report the case of a patient with severe OCD and SSRI-induced bruxism successfully treated with low-dose aripiprazole.
Abdominal Migraine
Abdominal migraine is a diagnostically challenging disorder, characterized by recurrent episodes of abdominal pain. Our findings demonstrate that abdominal migraine occurs and should be considered in the differential diagnosis of recurrent abdominal pain in adults, especially if there is a family history of migraine headaches.
B Vitamins Can Reduce Pain
B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats Life Sci. 2012 Aug 24; Kopruszinski CM, Reis RC, Chichorro JG Abstract AIMS: There is mounting evidence that use of B vitamins can help control neuropathic pain. This study investigated if treatment with B1, B6 and B12 vitamins, alone or in combination [...]
Seroquel Reduces Autoimmune-Mediated Demyelination and IL-2
Quetiapine, an Atypical Antipsychotic, Is Protective against Autoimmune-Mediated Demyelination by Inhibiting Effector T Cell Proliferation Feng Mei, Sheng Guo, Yangtao He, Linyun Wang, Hongkai Wang, Jianqin Niu, Jiming Kong, Xinmin Li, Yuzhang Wu, Lan Xiao PLoS One. 2012;7(8):e42746. Epub 2012 Aug 13. Abstract Quetiapine (Que), a commonly used atypical antipsychotic drug (APD), can prevent myelin [...]
Losartan Reduces Fibrosis and Improves Muscle Strength in Muscular Dystrophy Model
Losartan, a therapeutic candidate in congenital muscular dystrophy: studies in the dy(2J) /dy(2J) mouse Ann Neurol. 2012 May;71(5):699-708 Elbaz M, Yanay N, Aga-Mizrachi S, Brunschwig Z, Kassis I, Ettinger K, Barak V, Nevo Y Abstract OBJECTIVE: Lamininα2-deficient congenital muscular dystrophy type 1A (MDC1A) is a cureless disease associated with severe disability and shortened lifespan. Previous [...]
Vitamin D Reduces Multiple Sclerosis Lesions
Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis Ann Neurol. 2012 Aug;72(2):234-40 Mowry EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR, Gourraud PA, Brenneman D, Owen MC, Qualley P, Bucci M, Hauser SL, Pelletier D Abstract OBJECTIVE: We sought to determine whether vitamin D status is associated [...]
Inflammatory Cytokine Cause Cognitive Impairment, Depression, And Sleep Disturbance And Other Non-Motor Symptoms Of Parkinsons Disease
The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson’s disease. Psychosomatics. 2010 Nov-Dec;51(6):474-9. Menza M, Dobkin RD, Marin H, Mark MH, Gara M, Bienfait K, Dicke A, Kusnekov A. Abstract BACKGROUND:Parkinson’s disease (PD) affects patients’ lives with more than just physical impairment. Many of the non-motor aspects of PD, such as [...]
Eye Movement Tests For Schizophrenia
Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy. Biol Psychiatry. 2012 May 22; Authors: Benson PJ, Beedie SA, Shephard E, Giegling I, Rujescu D, St Clair D Abstract BACKGROUND: We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control [...]
Does this mean Viagra can treat depression?
Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model Cytokine. 2012 Jun 30; Authors: Nunes AK, Rapôso C, Luna RL, Cruz-Höfling MA, Peixoto CA Abstract Sildenafil induces cGMP accumulation through phosphodiesterase-5 (PDE5) inhibition. cGMP-pathways protect oligodendrocytes and modulate astroglial and microglial reactions. Microglia and astrocytes play an important role in [...]
Selenium slows memory decline – Reducing acetylcholinesterase activity
Organoselenium improves memory decline in mice: Involvement of acetylcholinesterase activity. Neurosci Lett. 2010 Jan 29; Authors: Pinton S, Rocha JT, Zeni G, Nogueira CW The present study was designed to investigate the possible neuroprotective effect of p,p’-methoxyl-diphenyl diselenide [(MeOPhSe)(2)] in a model of sporadic dementia of Alzheimer’s type (SDAT) induced by intracerebroventricular (i.c.v.) injection of [...]
Selenium prevents cognitive decline and oxidative damage
Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type. Brain Res. 2009 Jul 24;1281:117-27. Epub 2009 Apr 15. Ishrat T, Parveen K, Khan MM, Khuwaja G, Khan MB, Yousuf S, Ahmad A, Shrivastav P, Islam F. Department of Medical Elementology and Toxicology, Neurotoxicology Laboratory, Jamia Hamdard (Hamdard [...]
Brain Scan for Post-Traumatic Stress Disorder
Brain Scan Offers First Biological Test in Diagnosis of Post-Traumatic Stress Disorder Scientific American – Psychiatry 1/22/10 Carina Storrs The synchronous neural interactions test as a functional neuromarker for post-traumatic stress disorder (PTSD): a robust classification method based on the bootstrap. J Neural Eng. 2010 Feb;7(1):16011. Epub 2010 Jan 20. Georgopoulos AP, Tan HR, Lewis [...]
Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia.
Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia. Psychosom Med. 2009 Jun;71(5):566-73 Authors: Burgmer M, Gaubitz M, Konrad C, Wrenger M, Hilgart S, Heuft G, Pfleiderer B OBJECTIVE: Studies in fibromyalgia syndrome with functional neuroimaging support the hypothesis of central pain augmentation. To determine whether structural changes in [...]
Testosterone for Migraine
Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2009 Oct;66(4):564-8 Authors: Eikermann-Haerter K, Baum MJ, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused by mutations in the CACNA1A gene. Mutant mice carrying [...]
Role of endogenous testosterone concentration in pediatric stroke.
Role of endogenous testosterone concentration in pediatric stroke. Ann Neurol. 2009 Dec;66(6):754-8 Authors: Normann S, de Veber G, Fobker M, Langer C, Kenet G, Bernard TJ, Fiedler B, Sträter R, Goldenberg NA, Nowak-Göttl U Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in [...]
The Subthalamic Nucleus and Impulsivity
Stimulation of the subthalamic nucleus and impulsivity: release your horses. Ann Neurol. 2009 Dec;66(6):817-24 Authors: Ballanger B, van Eimeren T, Moro E, Lozano AM, Hamani C, Boulinguez P, Pellecchia G, Houle S, Poon YY, Lang AE, Strafella AP OBJECTIVE: In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute [...]
Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations.
Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations. Arch Neurol. 2010 Jan;67(1):126-30 Authors: Debs R, Depienne C, Rastetter A, Bellanger A, Degos B, Galanaud D, Keren B, Lyon-Caen O, Brice A, Sedel F OBJECTIVE: To report the first 2 European cases of biotin-responsive basal ganglia disease and novel SLC19A3 mutations. DESIGN: Case [...]
Muscarinic Agonists for the Treatment of Cognition in Schizophrenia
Muscarinic Agonists for the Treatment of Cognition in Schizophrenia Angela K. Sellin, MD, Mujeeb Shad, MD, and Carol Tamminga, MD CNS Spectr. 2008;13(11):985-996 It is widely accepted that cholinergic activity at muscarinic receptors is required to maintain cognitive functions, including learning and memory. Memory domains are especially impaired in schizophrenia, which may explain difficulties in [...]
Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants.
Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants. Related Articles Biol Psychol. 2009 Apr;81(1):31-9 Authors: Dorn LD, Kolko DJ, Susman EJ, Huang B, Stein H, Music E, Bukstein OG Hormone differences by psychopathology group and gender may have implications for understanding disruptive behavior disorders (DBDs) [...]
