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Neurology

Selenium slows memory decline – Reducing acetylcholinesterase activity

by Romeo Mariano, MD (February 7, 2010)

Organoselenium improves memory decline in mice: Involvement of acetylcholinesterase activity. Neurosci Lett. 2010 Jan 29; Authors: Pinton S, Rocha JT, Zeni G, Nogueira CW The present study was designed to investigate the possible neuroprotective effect of p,p’-methoxyl-diphenyl diselenide [(MeOPhSe)(2)] in a model of sporadic dementia of Alzheimer’s type (SDAT) induced by intracerebroventricular (i.c.v.) injection of [...]

Selenium prevents cognitive decline and oxidative damage

by Romeo Mariano, MD (February 7, 2010)

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type. Brain Res. 2009 Jul 24;1281:117-27. Epub 2009 Apr 15. Ishrat T, Parveen K, Khan MM, Khuwaja G, Khan MB, Yousuf S, Ahmad A, Shrivastav P, Islam F. Department of Medical Elementology and Toxicology, Neurotoxicology Laboratory, Jamia Hamdard (Hamdard [...]

Brain Scan for Post-Traumatic Stress Disorder

by Romeo Mariano, MD (January 27, 2010)

Brain Scan Offers First Biological Test in Diagnosis of Post-Traumatic Stress Disorder Scientific American – Psychiatry 1/22/10 Carina Storrs The synchronous neural interactions test as a functional neuromarker for post-traumatic stress disorder (PTSD): a robust classification method based on the bootstrap. J Neural Eng. 2010 Feb;7(1):16011. Epub 2010 Jan 20. Georgopoulos AP, Tan HR, Lewis [...]

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Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia.

by Romeo Mariano, MD (January 17, 2010)

Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia. Psychosom Med. 2009 Jun;71(5):566-73 Authors: Burgmer M, Gaubitz M, Konrad C, Wrenger M, Hilgart S, Heuft G, Pfleiderer B OBJECTIVE: Studies in fibromyalgia syndrome with functional neuroimaging support the hypothesis of central pain augmentation. To determine whether structural changes in [...]

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Testosterone for Migraine

by Romeo Mariano, MD (January 16, 2010)

Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2009 Oct;66(4):564-8 Authors: Eikermann-Haerter K, Baum MJ, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused by mutations in the CACNA1A gene. Mutant mice carrying [...]

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Role of endogenous testosterone concentration in pediatric stroke.

by Romeo Mariano, MD (January 16, 2010)

Role of endogenous testosterone concentration in pediatric stroke. Ann Neurol. 2009 Dec;66(6):754-8 Authors: Normann S, de Veber G, Fobker M, Langer C, Kenet G, Bernard TJ, Fiedler B, Sträter R, Goldenberg NA, Nowak-Göttl U Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in [...]

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The Subthalamic Nucleus and Impulsivity

by Romeo Mariano, MD (January 16, 2010)

Stimulation of the subthalamic nucleus and impulsivity: release your horses. Ann Neurol. 2009 Dec;66(6):817-24 Authors: Ballanger B, van Eimeren T, Moro E, Lozano AM, Hamani C, Boulinguez P, Pellecchia G, Houle S, Poon YY, Lang AE, Strafella AP OBJECTIVE: In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute [...]

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Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations.

by Romeo Mariano, MD (January 13, 2010)

Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations. Arch Neurol. 2010 Jan;67(1):126-30 Authors: Debs R, Depienne C, Rastetter A, Bellanger A, Degos B, Galanaud D, Keren B, Lyon-Caen O, Brice A, Sedel F OBJECTIVE: To report the first 2 European cases of biotin-responsive basal ganglia disease and novel SLC19A3 mutations. DESIGN: Case [...]

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Muscarinic Agonists for the Treatment of Cognition in Schizophrenia

by Romeo Mariano, MD (January 13, 2010)

Muscarinic Agonists for the Treatment of Cognition in Schizophrenia Angela K. Sellin, MD, Mujeeb Shad, MD, and Carol Tamminga, MD CNS Spectr. 2008;13(11):985-996 It is widely accepted that cholinergic activity at muscarinic receptors is required to maintain cognitive functions, including learning and memory. Memory domains are especially impaired in schizophrenia, which may explain difficulties in [...]

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Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants.

by Romeo Mariano, MD (January 13, 2010)

Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants. Related Articles Biol Psychol. 2009 Apr;81(1):31-9 Authors: Dorn LD, Kolko DJ, Susman EJ, Huang B, Stein H, Music E, Bukstein OG Hormone differences by psychopathology group and gender may have implications for understanding disruptive behavior disorders (DBDs) [...]

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