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Neuroendocrinology

Obesity with Insulin Resistance Is Associated with a Proinflammatory and Prothrombotic State

by Romeo Mariano, MD (January 18, 2010)

Obesity without Established Comorbidities of the Metabolic Syndrome Is Associated with a Proinflammatory and Prothrombotic State, Even before the Onset of Puberty in Children. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Mauras N, Delgiorno C, Kollman C, Bird K, Morgan M, Sweeten S, Balagopal P, Damaso L Background: Metabolic syndrome (MS)-related comorbidities in obesity, [...]

Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids

by Romeo Mariano, MD (January 17, 2010)

Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: insights from in vivo cell trafficking dynamics in rhesus macaques. Psychosom Med. 2009 Jul;71(6):591-7 Authors: Cole SW, Mendoza SP, Capitanio JP OBJECTIVE: To determine whether chronic social stress can desensitize leukocytes to normal physiologic regulation by endogenous glucocorticoids. METHODS: We analyzed the longitudinal relationship between plasma [...]

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Testosterone for Migraine

by Romeo Mariano, MD (January 16, 2010)

Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2009 Oct;66(4):564-8 Authors: Eikermann-Haerter K, Baum MJ, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused by mutations in the CACNA1A gene. Mutant mice carrying [...]

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Endocrine consequences of opioid therapy.

by Romeo Mariano, MD (January 14, 2010)

Endocrine consequences of opioid therapy. Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S162-8 Authors: Aloisi AM, Aurilio C, Bachiocco V, Biasi G, Fiorenzani P, Pace MC, Paci V, Pari G, Passavanti G, Ravaioli L, Sindaco G, Vellucci R, Ceccarelli I Gonadal hormones are known to be affected by morphine and other opioids. In this paper, we summarize data [...]

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Major depressive disorder and high cortisol levels: Textbook results that I hardly see in real life.

by Romeo Mariano, MD (January 14, 2010)

Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study.: “ Related Articles Arch Gen Psychiatry. 2009 Jun;66(6):617-26 Authors: Vreeburg SA, Hoogendijk WJ, van Pelt J, Derijk RH, Verhagen JC, van Dyck R, Smit JH, Zitman FG, Penninx BW CONTEXT: There is a central belief that depression is associated with hyperactivity of [...]

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Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production.

by Romeo Mariano, MD (January 13, 2010)

Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production. Related Articles Biol Psychol. 2009 Sep;82(1):12-7 Authors: Prather AA, Marsland AL, Hall M, Neumann SA, Muldoon MF, Manuck SB Activation of innate inflammatory pathways, marked by increased production of pro-inflammatory cytokines, has been proposed as a potential mechanism linking [...]

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Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants.

by Romeo Mariano, MD (January 13, 2010)

Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants. Related Articles Biol Psychol. 2009 Apr;81(1):31-9 Authors: Dorn LD, Kolko DJ, Susman EJ, Huang B, Stein H, Music E, Bukstein OG Hormone differences by psychopathology group and gender may have implications for understanding disruptive behavior disorders (DBDs) [...]

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Transient responses of inflammatory cytokines in acute stress.

by Romeo Mariano, MD (January 13, 2010)

Transient responses of inflammatory cytokines in acute stress.: Related Articles Biol Psychol. 2009 Sep;82(1):25-32 Authors: Yamakawa K, Matsunaga M, Isowa T, Kimura K, Kasugai K, Yoneda M, Kaneko H, Ohira H It has been demonstrated that concentrations of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are elevated by acute stress. Although several studies [...]

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Day-to-day variation in saliva cortisol–relation with sleep, stress and self-rated health.

by Romeo Mariano, MD (January 13, 2010)

Day-to-day variation in saliva cortisol–relation with sleep, stress and self-rated health. Related Articles Biol Psychol. 2009 Oct;82(2):149-55 Authors: Dahlgren A, Kecklund G, Theorell T, Akerstedt T The objective was to examine the day-to-day variation in cortisol among healthy individuals and its relation to the time of saliva sampling, work, stress and fatigue. During 4 consecutive [...]

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Sleep physiology in recovery from burnout.

by Romeo Mariano, MD (January 13, 2010)

Sleep physiology in recovery from burnout. Related Articles Biol Psychol. 2009 Dec;82(3):267-73 Authors: Ekstedt M, Söderström M, Akerstedt T This study aimed to investigate the role of sleep physiology in recovery from burnout, in particular the relation between sleep and changes in fatigue and whether those changes would be related to return to work. 23 [...]

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