From the category archives:

Neural Circuitry

Emotions and Hallucinations – Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations

by Romeo Mariano, MD (January 18, 2010)

Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations: An fMRI study using independent component analysis. Schizophr Res. 2010 Jan 11; Authors: Escartí MJ, de la Iglesia-Vayá M, Martí-Bonmatí L, Robles M, Carbonell J, Lull JJ, García-Martí G, Manjón JV, Aguilar EJ, Aleman A, Sanjuán J OBJECTIVE: Hallucinations in patients with schizophrenia [...]

Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia.

by Romeo Mariano, MD (January 17, 2010)

Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia. Psychosom Med. 2009 Jun;71(5):566-73 Authors: Burgmer M, Gaubitz M, Konrad C, Wrenger M, Hilgart S, Heuft G, Pfleiderer B OBJECTIVE: Studies in fibromyalgia syndrome with functional neuroimaging support the hypothesis of central pain augmentation. To determine whether structural changes in [...]

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The Subthalamic Nucleus and Impulsivity

by Romeo Mariano, MD (January 16, 2010)

Stimulation of the subthalamic nucleus and impulsivity: release your horses. Ann Neurol. 2009 Dec;66(6):817-24 Authors: Ballanger B, van Eimeren T, Moro E, Lozano AM, Hamani C, Boulinguez P, Pellecchia G, Houle S, Poon YY, Lang AE, Strafella AP OBJECTIVE: In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute [...]

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N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania

by Romeo Mariano, MD (January 13, 2010)

N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Related Articles Arch Gen Psychiatry. 2009 Jul;66(7):756-63 Authors: Grant JE, Odlaug BL, Kim SW CONTEXT: Trichotillomania is characterized by repetitive hair pulling that causes noticeable hair loss. Data on the pharmacologic treatment of trichotillomania are limited to conflicting studies of serotonergic medications. [...]

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Muscarinic Agonists for the Treatment of Cognition in Schizophrenia

by Romeo Mariano, MD (January 13, 2010)

Muscarinic Agonists for the Treatment of Cognition in Schizophrenia Angela K. Sellin, MD, Mujeeb Shad, MD, and Carol Tamminga, MD CNS Spectr. 2008;13(11):985-996 It is widely accepted that cholinergic activity at muscarinic receptors is required to maintain cognitive functions, including learning and memory. Memory domains are especially impaired in schizophrenia, which may explain difficulties in [...]

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Functional Disconnection of Frontal Cortex and Visual Cortex in Attention-Deficit/Hyperactivity Disorder.

by Romeo Mariano, MD (January 13, 2010)

Functional Disconnection of Frontal Cortex and Visual Cortex in Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry. 2010 Jan 6; Authors: Mazaheri A, Coffey-Corina S, Mangun GR, Bekker EM, Berry AS, Corbett BA BACKGROUND: Current pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) suggest that impaired functional connectivity within brain attention networks may contribute to the disorder. In this electroencephalographic (EEG) [...]

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A beta(3)-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress.

by Romeo Mariano, MD (January 13, 2010)

A beta(3)-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress. Biol Psychiatry. 2010 Jan 8; Authors: Chuang JC, Krishnan V, Yu HG, Mason B, Cui H, Wilkinson MB, Zigman JM, Elmquist JK, Nestler EJ, Lutter M BACKGROUND: Obesity has been associated with an increased risk of developing several psychiatric illnesses, including major depression [...]

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Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.

by Romeo Mariano, MD (January 12, 2010)

Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. J Neuroimmunol. 2010 Jan 8; [...]

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Decreased Frontal Serotonin2A Receptor Binding in Antipsychotic-Naive Patients With First-Episode Schizophrenia

by Romeo Mariano, MD (January 11, 2010)

Decreased Frontal Serotonin2A Receptor Binding in Antipsychotic-Naive Patients With First-Episode Schizophrenia [Original Article] Arch Gen Psychiatry. 2010;67(1):9-16. Hans Rasmussen, PhD; David Erritzoe, MD, PhD; Rune Andersen, MSc; Bjorn H. Ebdrup, MD; Bodil Aggernaes, MD, PhD; Bob Oranje, PhD; Jan Kalbitzer, MD; Jacob Madsen, PhD; Lars H. Pinborg, MD, DMSc; William Baaré, PhD; Claus Svarer, PhD; [...]

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To Sleep, Perchance to Reset Your Body Clock

by Romeo Mariano, MD (January 11, 2010)

To Sleep, Perchance to Reset Your Body Clock January 9, 2010 Psychiatric Times. Vol. 27 No. 2 Alfred J. Lewy, MD, PhD Dr Lewy is professor of psychiatry, ophthalmology, and physiology/pharmacology, senior vice chairman of the department of psychiatry, and director of the sleep and mood disorders laboratory at the Oregon Health & Science University, [...]

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