From the category archives:

Medications

Pergolide Reduces Cognitive Deficits Associated with Schizotypal Personality Disorder

by Romeo Mariano, MD (February 6, 2010)

Pergolide Treatment of Cognitive Deficits Associated with Schizotypal Personality Disorder: Continued Evidence of the Importance of the Dopamine System in the Schizophrenia Spectrum. Neuropsychopharmacology. 2010 Feb 3; Authors: McClure MM, Harvey PD, Goodman M, Triebwasser J, New A, Koenigsberg HW, Sprung LJ, Flory JD, Siever LJ Cognitive deficits observed in schizophrenia are also frequently found [...]

Levetiracetam inhibits interleukin-1beta inflammatory responses in the hippocampus and piriform cortex

by Romeo Mariano, MD (January 20, 2010)

Levetiracetam inhibits interleukin-1beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. Neurosci Lett. 2010 Jan 14; Authors: Kim JE, Choi HC, Song HK, Jo SM, Kim DS, Choi SY, Kim YI, Kang TC Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra(R), UCB Pharma) is a new antiepileptic drug used to treat certain types of seizures in [...]

Thiazolidinedione associated with increased Risk of Fractures in Patients with Type 2 Diabetes Mellitus.

by Romeo Mariano, MD (January 18, 2010)

Thiazolidinedione Use and the Longitudinal Risk of Fractures in Patients with Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Habib ZA, Havstad SL, Wells K, Divine G, Pladevall M, Williams LK Context: Thiazolidinedione (TZD) use has recently been associated with an increased risk of fractures. Objective: The aim of this study [...]

N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania

by Romeo Mariano, MD (January 13, 2010)

N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Related Articles Arch Gen Psychiatry. 2009 Jul;66(7):756-63 Authors: Grant JE, Odlaug BL, Kim SW CONTEXT: Trichotillomania is characterized by repetitive hair pulling that causes noticeable hair loss. Data on the pharmacologic treatment of trichotillomania are limited to conflicting studies of serotonergic medications. [...]

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Muscarinic Agonists for the Treatment of Cognition in Schizophrenia

by Romeo Mariano, MD (January 13, 2010)

Muscarinic Agonists for the Treatment of Cognition in Schizophrenia Angela K. Sellin, MD, Mujeeb Shad, MD, and Carol Tamminga, MD CNS Spectr. 2008;13(11):985-996 It is widely accepted that cholinergic activity at muscarinic receptors is required to maintain cognitive functions, including learning and memory. Memory domains are especially impaired in schizophrenia, which may explain difficulties in [...]

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Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.

by Romeo Mariano, MD (January 12, 2010)

Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. J Neuroimmunol. 2010 Jan 8; [...]

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Effect of acute antidepressant administration on negative affective bias in depressed patients.

by Romeo Mariano, MD (January 11, 2010)

Effect of acute antidepressant administration on negative affective bias in depressed patients. Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry. 2009 Oct;166(10):1178-84 Authors: Harmer CJ, O’Sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A, Goodwin GM, Cowen PJ OBJECTIVE: Acute administration of an antidepressant increases positive affective [...]

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Testosterone Augmentation Therapy Reduces Major Depressive Disorder Severity

by Romeo Mariano, MD (January 10, 2010)

Low-dose Transdermal Testosterone Augmentation Therapy Improves Depression Severity in Women Karen K. Miller, MD, Roy H. Perlis, MD, MSc, George I. Papakostas, MD, David Mischoulon, MD, PhD, Dan V. Iosifescu, MD, MSc, Danielle J. Brick, BA, and Maurizio Fava, MD CNS Spectr. 2009;14(12):688-694 [download PDF] Background: Inadequate response to antidepressant monotherapy in women with major [...]

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Is Heart Failure a Mental Illness? – MAO Inhibitors offers promise in treating heart failure

by Romeo Mariano, MD (January 10, 2010)

Is Heart Failure a mental illness? At the very least, it is a psychosomatic illness as this press release indicates. ———- Public release date: 6-Jan-2010 Contact: David March dmarch1@jhmi.edu 410-955-1534 Johns Hopkins Medical Institutions Old antidepressant offers promise in treating heart failure Monoamine oxidase-A inhibitor drug blocks buildup of toxic free radicals in animal hearts [...]

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Smoking Cessation Pharmacotherapy Does Not Work Well

by Romeo Mariano, MD (January 10, 2010)

Comparative Effectiveness of 5 Smoking Cessation Pharmacotherapies in Primary Care Clinics [Original Investigation] Stevens S. Smith, PhD; Danielle E. McCarthy, PhD; Sandra J. Japuntich, PhD; Bruce Christiansen, PhD; Megan E. Piper, PhD; Douglas E. Jorenby, PhD; David L. Fraser, MS; Michael C. Fiore, MD, MPH; Timothy B. Baker, PhD; Thomas C. Jackson, MD Arch Intern [...]

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