NEW ARTICLES

An Epidemic: 1 in 3 Adults in the United States has High Blood Pressure

| 2015.12.05

http://www.fda.gov/forconsumers/consumerupdates/ucm048534.htm Medications for High Blood Pressure Nearly one in three adults in the United States has high blood pressure, also called hypertension. High blood pressure is dangerous because it increases the risk of stroke, heart attack, heart failure, kidney failure, death. “High blood pressure is often called the ‘silent killer’ because it usually has no […]

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Clozapine is Better than Standard Antipsychotics for Reducing Schizophrenia Hospitalizations but has Greater Health Risks

| 2015.11.22

Comparative Effectiveness of Clozapine and Standard Antipsychotic Treatment in Adults With Schizophrenia. Am J Psychiatry. 2015 Nov 6;:appiajp201515030332 Authors: Stroup TS, Gerhard T, Crystal S, Huang C, Olfson M Abstract OBJECTIVE: The authors compared the effectiveness of initiating treatment with either clozapine or a standard antipsychotic among adults with evidence of treatment-resistant schizophrenia in routine […]

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Vitamin A Deficiency Leads to Diabetes and Obesity

| 2015.11.21

Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components Rev Paul Pediatr. 2014 Mar;32(1):50-4 Authors: Teske M, Melges AP, de Souza FI, Fonseca FL, Sarni RO OBJECTIVE: To evaluate obese children and adolescents’ retinol plasma levels and to correlate them with metabolic syndrome components. METHODS: Cross-sectional study with 61 obese […]

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Vitamin A and D deficiency Increases Obesity Risk

| 2015.11.21

Restriction of vitamin A and D in beef cattle finishing diets on feedlot performance and adipose accretion J Anim Sci. 2012 Jun;90(6):1866-78. doi: 10.2527/jas.2010-3590. Epub 2011 Dec 16. Authors: Pickworth CL1, Loerch SC, Fluharty FL. In the United States, intramuscular adipose tissue (marbling) in cattle is associated with consumer satisfaction of beef products (Killinger et […]

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Immune Activation in Schizophrenia

| 2015.11.21

Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia Am J Psychiatry. 2015 Jul 2;:appiajp201515010019 Authors: Volk DW, Chitrapu A, Edelson JR, Roman KM, Moroco AE, Lewis DA OBJECTIVE:  Immune-related abnormalities are commonly reported in schizophrenia, including higher mRNA levels for the viral restriction factor interferon-induced transmembrane protein (IFITM) in the prefrontal cortex. The […]

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tDCS reduces auditory hallucinations in schizophrenia

| 2015.11.21

Effect of tDCS on auditory hallucinations in schizophrenia: Influence of catechol-O-methyltransferase (COMT) Val158Met polymorphism Asian J Psychiatr. 2015 Jun 2; Authors: Shivakumar V, Chhabra H, Subbanna M, Agarwal SM, Bose A, Kalmady SV, Narayanaswamy JC, Debnath M, Venkatasubramanian G   Dysregulated cortical plasticity has been demonstrated to underlie the pathogenesis of positive symptoms like auditory […]

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Vitamin A Regulates Lipid Metabolism

| 2015.11.21

Retinoid X receptor: the forgotten partner in regulating lipid metabolism? Am J Clin Nutr. 2015 Jun 10;  Authors: Neuschwander-Tetri BA People with non-alcoholic fatty liver disease have lower circulating RA concentrations than do normal controls.  The differences were not trivial, with concentrations in those having severe NASH being less than half the concentrations in controls.  Hepatic expression […]

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Fat as an endocrine organ regulating metabolism

| 2015.11.21

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis Neuropharmacology. 2012 Jul;63(1):57-75 Authors: Harwood HJ Abstract Over the past decade and a half it has become increasingly clear that adipose tissue is a much more complex organ than was initially considered and that its metabolic functions extend well beyond the classical actions […]

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Activation of immune responses to brain antigens after stroke.

| 2015.11.21

Activation of immune responses to brain antigens after stroke.   Activation of immune responses to brain antigens after stroke. J Neurochem. 2012 Nov;123 Suppl 2:148-55 Authors: Becker KJ Abstract Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically […]

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Prazosin for Combat Trauma PTSD in Active-Duty Soldiers Returned From Iraq and Afghanistan.

| 2015.11.21

A Trial of Prazosin for Combat Trauma PTSD With Nightmares in Active-Duty Soldiers Returned From Iraq and Afghanistan Am J Psychiatry. 2013 Jul 12; Authors: Raskind MA, Peterson K, Williams T, Hoff DJ, Hart K, Holmes H, Homas D, Hill J, Daniels C, Calohan J, Millard SP, Rohde K, O’Connell J, Pritzl D, Feiszli K, […]

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Carnosine for Depressive Disorders.

| 2015.11.21

Possible Benefit of Dietary Carnosine towards Depressive Disorders. Aging Dis. 2015 Sep;6(5):300 Authors: Hipkiss AR Many stress-related and depressive disorders have been shown to be associated with one or more of the following; shortened telomeres, raised cortisol levels and increased susceptibility to age-related dysfunction. It is suggested here that insufficient availability of the neurological peptide, […]

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The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease.

| 2015.11.20

The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease Aging Dis. 2015 Sep;6(5):331-41  Authors: Budni J, Bellettini-Santos T, Mina F, Garcez ML, Zugno AI   Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer’s […]

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Low HbA1c and Increased Mortality Risk

| 2015.11.20

Low HbA1c and Increased Mortality Risk-is Frailty a Confounding Factor?:  Aging Dis. 2015 Aug;6(4):262-70 Authors: Abdelhafiz AH, Sinclair AJ Diabetes mellitus is increasingly becoming an older person disease due to the increased survival and aging of the population. Previous studies which showed benefits of tight glycemic control and a linear relationship between HbA1c and mortality […]

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Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder.

| 2015.11.20

Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder.: “ Related Articles Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder. Am J Psychiatry. 2013 Jul 12; Authors: Jarskog LF, Hamer RM, Catellier DJ, Stewart DD, Lavange L, Ray N, Golden LH, Lieberman […]

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Why you’re hungry after eating Chinese food – It’s the rice

| 2013.07.17

Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr. 2013 Jun 26; Authors: Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS Abstract BACKGROUND: Qualitative aspects of diet influence eating behavior, but the physiologic mechanisms for these calorie-independent […]

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Green tea improves glucose control and insulin sensitivity

| 2013.07.17

Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Am J Clin Nutr. 2013 Jun 26; Authors: Liu K, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, Mi MT Abstract BACKGROUND: The results of studies investigating the effect of green tea on glucose control and […]

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Transcranial direct-current stimulation (tDCS) for hallucinations in schizophrenia

| 2013.07.14

Examining transcranial direct-current stimulation (tDCS) as a treatment for hallucinations in schizophrenia. Am J Psychiatry. 2012 Jul 1;169(7):719-24 Authors: Brunelin J, Mondino M, Gassab L, Haesebaert F, Gaha L, Suaud-Chagny MF, Saoud M, Mechri A, Poulet E   Abstract OBJECTIVE: Some 25%–30% of patients with schizophrenia have auditory verbal hallucinations that are refractory to antipsychotic […]

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Blocking Pro-inflammatory Tumor Necrosis Factor with Remicade for Treatment-Resistant Depression

| 2012.11.08

Increased concentrations of inflammatory biomarkers predict antidepressant nonresponse, and inflammatory cytokines can sabotage and circumvent the mechanisms of action of conventional antidepressants. A drug that targets inflammation may assist in the treatment of depression in individuals with high levels of inflammation. Results of a proof-of-concept study by him, Charles Raison, M.D., an associate professor of psychiatry at the University of Arizona, and colleagues showed that a biologic medication was able to reduce depressive symptoms in some subjects who had suffered from major depression for an average of 15 years.

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Screening For Depression In Patients With Diabetes

| 2012.10.27

The prevalence of depression is increased in people with diabetes and there are both national and international recommendations for screening of depression in people with diabetes. Most screening is currently sporadic and there are no formal screening programs. Further research is needed to evaluate the most clinically effective and cost effective way of doing so in structured screening programs.

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Citalopram, QTc Interval Prolongation, and Torsade de Pointes

| 2012.10.15

Recently, both the manufacturer of citalopram and the US Food and Drug Administration have warned health care providers and patients about new information implicating drug-induced QTc interval prolongation and torsade de pointes when using citalopram in doses >40 mg/day. This warning is not placed in the context of either benefits or risks in real-world clinical practice, leaving clinicians with an untenable choice between depriving patients of high-dose citalopram or malpractice litigation. We reviewed the literature and found no cases of citalopram-induced sudden cardiac death among patients taking up to 60 mg/day of citalopram and free of risk factors for QTc interval prolongation and torsade de pointes. Because psychotropic drug-induced sudden cardiac death is an outlier in the absence of identified risk factors for QTc interval prolongation and torsade de pointes, we do not believe current Phase 3 and Phase 4 studies provide sufficient information to limit current prescribing practices for citalopram (20 mg to 60 mg/day).

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